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Dr. Laurent Malaquin, Director de Recherche, ELiA, LAAS-CNRS

Event Date: 
Monday, November 5, 2018 - 3:30pm to 4:30pm

Microfluidic Devices for Cell Culture and Analysis

Microtechnologies and microfluidics have shown considerable promise for improving the fields of biomedical science and clinical diagnostics. After undergoing its own development and establishment as a technology over past years, microfluidics is now being increasingly applied to areas such as biomarker analysis where it has the potential to transform the field. It offers the possibility to select, manipulate, stimulate, individual cells or even molecules, in a highly parallelized and automated manner. It thus provides all the basic functions that are required to perform the complex analytical workflows leading to biomarker detection and quantitation. In this talk, I will first show three examples of bio-analytical applications that we recently developed for i) the integration of functionalized 3D structures for protein detection and capture of rare cancerous cells ii) the generation of a miniaturized fluidized bed for bio molecular pre-concentration iii) the use of droplet microfluidics  for multiplexed heterogeneous immuno-assays and transcriptomic analysis through RT PCR.  I will finally introduce some technological developments that have been recently started at LAAS CNRS on the development of 3D printing technologies for the fabrication of 3D microfluidic devices and the integration of scaffolds recapitulating some topological and physical properties of cell microenvironments.

Dr Laurent Malaquin received his PhD in Nanotechnology in 2004 at the P. Sabatier University of Toulouse. He spent two years as a post-doctoral student at the IBM Zurich research laboratory (Switzerland) where he developed self-assembly and microfluidics concepts for the integration of functional nanoparticles. He then joined the Curie Institute (Paris, France) where he worked during 8 years in close collaborations with biologists and clinicians on the development of miniaturized integrated systems (microfluidics, lab-on-chips, etc.) for sample processing, analysis of cancer biomarkers and diagnostic applications.  Since 2015, Dr Malaquin joined the LAAS CNRS in Toulouse (France) where he continues his work at the interface between physics and biology. He is now developing 3D additive manufacturing technologies and microfluidic concepts for the creation of cell environments. Main applications concern the fabrication of 3D microenvironments for cell culture, the study of influence of cell heterogeneity on cancer mechanisms and the fabrication of artificial scaffold for bone implants. In 2016, L. Malaquin founded the Inorevia company (IPGG, Paris France) that develops automated microfluidic platforms for sample processing and analysis.


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