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V N Du Le Research Associate McMaster University

Event Date: 
Monday, September 25, 2017 - 3:30pm to 4:30pm

Tissue Phantoms for Optical Spectroscopy and Spectral Imaging

Tissue-simulating phantoms with controlled optical properties and/or physiological properties are critical for standardizing and evaluating the performance of optical spectroscopy and optical imaging systems. The selection criteria for the materials of optical phantoms critically depend on the region of spectrum and the target tissues that the technology applies to. The later determines the design parameters for the phantom such as its thickness, heterogeneities/layered structure, container, and machining constraints. Several articles have suggested that the best choices for scatters have been: Intralipid, titanium or aluminum oxide powders, and polymer microspheres whereas the choices for absorbers varies widely, depending on application. In this talk, simple fabrication methods for either liquid (with or without vessel-like structure) or gel-based optical phantoms using polymer microspheres, Intralipid, India ink, and hemoglobin (Hb) will be discussed. These phantoms aim to evaluate the performance of diffuse reflectance spectroscopy, fluorescence spectroscopy and spectral imaging. Particularly, Intralipid will be ruled out as material for optical phantoms in fluorescence spectroscopy studies due to its fluorescence properties, and a model for Hb-phantoms with controlled oxygen saturation (StO2) that is suitable for spectral imaging will be presented.

 

Du Le is a current Research Associate at McMaster University, and will join the Medical Physics Team at Juravinski Cancer Centre as Medical Physics Resident in October 2017. Previously, he received a PhD degree in Medical Physics (2016) from McMaster University, a Master’s degree (2010) and a Bachelor’s degree (2009) in Biomedical Engineering from the Catholic University of America. He was a Research Engineer at U.S. Food and Drug Administration (FDA) from 2010 to 2012. His past research aims to evaluate the potentials of optical spectroscopy and spectral imaging for non-invasive detection of tissue abnormalities.

Event Location: 
McMaster
Location Details: 
ABB-165